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OER and RBE for 125I and 192Ir at low dose rate on mammalian cells
E R Hering1, G R Sealy, P Dowman
1Department of Medical Physics, Groote Schuur Hospital, University of Cape Town, South Africa.
Abstract:
The oxygen enhancement ratio (OER) for 125I and 192Ir as well as the relative biological effectiveness (RBE) at low dose rates (40-80 cGy h-1) were determined for B16 melanoma cells in culture. The OER was found to be 2.1 +/- 0.03 for 125I and 2.7 +/- 0.04 for 192Ir. The RBE for 125I relative to 192Ir was determined as 1.8 +/- 0.03 under aerated conditions and as 2.4 +/- 0.03 under hypoxia.