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Intercellular Arc Signaling Regulates Vasodilation.

June Bryan de la Peña1, Paulino Barragan-Iglesias2,3, Tzu-Fang Lou1

  • 1Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas 75080.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 30, 2021
PubMed
Summary
This summary is machine-generated.

Nerve cells produce the Arc protein in response to inflammation, which helps control skin inflammation. This protein, released in extracellular vesicles (EVs), regulates neurogenic inflammation.

Keywords:
ArcDRGneuroinflamationnociceptorstranslational control

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Immunology

Background:

  • Skin injury involves cell communication, with sensory neurons influencing inflammation.
  • Activity-dependent protein synthesis in nociception and inflammation is poorly understood.

Purpose of the Study:

  • Investigate activity-dependent protein synthesis in response to inflammatory mediators.
  • Determine the role of the Arc gene in neurogenic inflammation.

Main Methods:

  • Ribosome profiling of murine dorsal root ganglion (DRG) neurons treated with inflammatory mediators.
  • Analysis of Arc-deficient mice and rescue experiments using Arc-containing extracellular vesicles (EVs).

Main Results:

  • Identified Arc as an activity-dependent translation target in DRG neurons.
  • Arc deficiency in mice led to exaggerated inflammatory responses (paw temperature, vasodilation).
  • Injection of Arc-containing EVs rescued exaggerated inflammatory responses in Arc-deficient mice.

Conclusions:

  • Activity-dependent Arc production in afferent nerve fibers regulates neurogenic inflammation.
  • Intercellular signaling via Arc-containing EVs plays a role in modulating skin inflammation.