Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

4.2K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.2K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

3.0K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
3.0K
Microtubules in Signaling01:22

Microtubules in Signaling

1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.7K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing and modeling cell-cell communication in 2D biomimetic tissues.

Soft matter·2026
Same author

Design and optimization of in situ self-functionalizing stress sensors.

The European physical journal. E, Soft matter·2026
Same author

Interaction of the mechanosensitive microswimmer <i>Paramecium</i> with obstacles.

Royal Society open science·2023
Same author

An electrophysiological and kinematic model of Paramecium, the "swimming neuron".

PLoS computational biology·2023
Same author

Collective stiffening of soft hair assemblies.

Physical review. E·2020
Same author

A simple device to immobilize protists for electrophysiology and microinjection.

The Journal of experimental biology·2020

Related Experiment Video

Updated: Oct 26, 2025

Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

11.3K

A bending fluctuation-based mechanism for particle detection by ciliated structures.

Jean-Baptiste Thomazo1,2, Benjamin Le Révérend3, Lea-Laetitia Pontani1

  • 1Laboratoire Jean Perrin, Institut de Biologie Paris-Seine, Sorbonne Université, CNRS, F-75005 Paris, France.

Proceedings of the National Academy of Sciences of the United States of America
|July 30, 2021
PubMed
Summary

Bending fluctuations of elastic fibers in granular suspensions reveal particle concentration. This study models particle-fiber interactions for understanding biological ciliary systems.

Keywords:
biomimetismciliatexture perception

More Related Videos

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

8.5K
Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

4.4K

Related Experiment Videos

Last Updated: Oct 26, 2025

Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

11.3K
Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

8.5K
Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency
11:13

Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Published on: November 10, 2021

4.4K

Area of Science:

  • Biophysics
  • Fluid Dynamics
  • Materials Science

Background:

  • Biological cilia are crucial for fluid transport and sensing.
  • Understanding cilia's mechanical response in complex fluids is challenging.
  • Passive biological cilia dynamics are not fully understood.

Purpose of the Study:

  • To mimic passive biological cilia's mechanical response in complex fluids.
  • To investigate the bending dynamics of an elastic fiber in a granular suspension under shear.
  • To establish a framework for particle detection by ciliated systems.

Main Methods:

  • Simulating the bending dynamics of an anchored elastic fiber.
  • Subjecting the fiber to a dilute granular suspension under shear flow.
  • Analyzing fiber bending fluctuations to detect particle concentration variations.
  • Developing a simple elastohydrodynamics model for particle/fiber interactions.

Main Results:

  • Fiber bending fluctuations accurately encode granular suspension concentration.
  • Individual particle passages induce measurable deflections in the fiber.
  • Particle-fiber contact is the dominant interaction mechanism.
  • The elastohydrodynamics model successfully predicts deflection amplitudes.

Conclusions:

  • Elastic fiber bending dynamics can serve as a sensor for particle concentration.
  • The study provides a mechanistic and statistical model for particle detection by cilia.
  • This research offers insights into the function of biological ciliated systems in complex fluids.