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Published on: September 20, 2021
Pseudoboehmite as a drug delivery system for acyclovir.
Renato Meneghetti Peres1, Jéssica Maiara Leme Sousa1, Mariana Oliva de Oliveira2
1School of Engineering, Mackenzie Presbyterian University, Rua da Consolação, 930, Building 33, Consolação, São Paulo, SP, 01302-907, Brazil.
Pseudoboehmite nanoparticles significantly enhance acyclovir
Area of Science:
- Nanotechnology
- Pharmacology
- Materials Science
Background:
- Herpes simplex virus infections are common.
- Acyclovir is an effective antiviral but has poor oral bioavailability due to low gastrointestinal permeability.
- Nanoparticles offer potential for improved drug delivery.
Purpose of the Study:
- To synthesize pseudoboehmite nanoparticles.
- To evaluate pseudoboehmite as a drug delivery system for acyclovir.
- To assess the impact of pseudoboehmite on acyclovir's oral bioavailability.
Main Methods:
- Sol-gel method for pseudoboehmite nanoparticle synthesis.
- Characterization using infrared spectroscopy, transmission electron microscopy, and X-ray diffraction.
- In vivo studies in Wistar rats comparing acyclovir with and without pseudoboehmite.
Main Results:
- High purity pseudoboehmite nanoparticles were successfully synthesized.
- Pseudoboehmite nanoparticles increased acyclovir plasma concentration by 4.6-fold after 4 hours in rats.
- Pseudoboehmite demonstrated low toxicity up to 10 mg/mL.
Conclusions:
- Pseudoboehmite nanoparticles are a promising system for improving acyclovir oral bioavailability.
- This approach could enhance systemic drug delivery for herpes simplex virus infections.
- Further research into pseudoboehmite-based drug delivery is warranted.
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