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Published on: December 17, 2021
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Tubulointerstitial nephritis and uveitis in Northern Ireland.
A Heaney1, E McLoone2, M Williams2
1Belfast Health and Social Care Trust, Belfast, UK. aheaney08@qub.ac.uk.
Eye (London, England)
|July 30, 2021
Summary
Tubulointerstitial nephritis and uveitis (TINU) affects both children and adults, with Northern Ireland patients showing an older average age at onset. Long-term immunosuppression was often needed for ocular inflammation, but renal outcomes remained good.
Area of Science:
- Ophthalmology
- Nephrology
- Immunology
Background:
- Tubulointerstitial nephritis and uveitis (TINU) is a rare condition affecting both pediatric and adult populations.
- Understanding the demographic distribution, treatment, and outcomes of TINU is crucial for patient management.
Purpose of the Study:
- To document the demographic distribution, treatment requirements, and visual and renal outcomes of patients diagnosed with TINU in Northern Ireland.
- To compare the characteristics of TINU patients in Northern Ireland with existing literature.
Main Methods:
- Retrospective data collection from 2011 to 2021 on 24 TINU patients.
- Utilized Northern Ireland Electronic Care Record, pathology records, and uveitis databases.
- Classified patients using the Mandeville classification system and uveitis using Standard Uveitis Nomenclature (SUN).
Main Results:
- Population prevalence estimated at 12.6 cases per million.
- 19 definite and 5 probable TINU cases identified; 17 had biopsy-positive TIN.
- Most patients presented with acute bilateral anterior uveitis; visual acuity was maintained, and no long-term renal impairment occurred.
Conclusions:
- TINU affects both pediatric and adult populations, with a notably older average age of onset in Northern Ireland compared to published data.
- Ongoing ocular inflammation, rather than renal issues, frequently necessitated long-term immunosuppression for uveitis management.
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