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Examining the Association Between Serum Leptin and Sarcopenic Obesity
Zhe-Yu Yang1,2, Wei-Liang Chen2,3,4
1Department of General Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Journal of Inflammation Research
|July 30, 2021
Summary
Higher serum leptin levels are linked to an increased risk of sarcopenic obesity in older adults. This finding suggests leptin may contribute to this geriatric syndrome.
Area of Science:
- Geriatric Medicine
- Endocrinology
- Nutritional Science
Background:
- Sarcopenic obesity is a complex geriatric syndrome in elderly individuals.
- The pathogenesis linking sarcopenia and obesity is intricate.
- Leptin, a pro-inflammatory adipokine, is suspected to be involved in sarcopenic obesity.
Purpose of the Study:
- To investigate the relationship between serum leptin levels and sarcopenic obesity in older adults.
- To determine if leptin is associated with the prevalence of sarcopenic obesity.
Main Methods:
- Analysis of 4063 participants aged 60+ from the NHANES III database.
- Sarcopenia defined by skeletal muscle index (SMI) < 1 SD below young adult mean.
- Obesity defined by body mass index (BMI) > 30 kg/m².
- Multivariate regression analysis to assess the association between serum leptin and sarcopenic obesity.
Main Results:
- Serum leptin positively correlated with BMI (β: 1.33, p<0.001) and negatively with SMI (β: -0.091, p=0.001).
- A significant association was found between serum leptin level and sarcopenic obesity (β: 4.011, p=0.014) in multivariate analysis.
Conclusions:
- Serum leptin levels are associated with an increased risk of sarcopenic obesity.
- Leptin may play a significant role in the development of sarcopenic obesity.
- These findings highlight a potential biomarker and therapeutic target for sarcopenic obesity.
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