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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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The Impact of Chronic Kidney Disease on Peripheral Artery Disease and Peripheral Revascularization

Raffaele Serra1,2, Umberto Marcello Bracale3, Nicola Ielapi4

  • 1Interuniversity Center of Phlebolymphology (CIFL), "Magna Graecia" University, Catanzaro, Italy.

International Journal of General Medicine
|July 30, 2021
PubMed

Insights

Peripheral artery disease (PAD) is more common in chronic kidney disease (CKD) patients. While revascularization can help, CKD patients face higher risks, necessitating further research into this association.

Area of Science:

  • Nephrology
  • Vascular Surgery
  • Cardiology

Background:

  • Chronic kidney disease (CKD) is a growing global health concern associated with high morbidity and mortality.
  • CKD is linked to increased risk of cardiovascular endpoints, including peripheral artery disease (PAD).
  • PAD prevalence significantly rises with CKD severity.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, and treatment outcomes of PAD in CKD patients.
  • To examine the association between CKD, PAD, and peripheral revascularization.
  • To highlight future research challenges and perspectives.

Main Methods:

  • Review of existing observational and intervention studies.
  • Analysis of epidemiological data on CKD and PAD prevalence.
  • Examination of pathophysiologic mechanisms linking CKD and PAD.

Main Results:

  • PAD is more prevalent in CKD patients, especially those with advanced disease.
  • Revascularization improves prognosis in PAD patients regardless of kidney function.
  • CKD patients undergoing revascularization exhibit increased risks of amputation, mortality, and complications.

Conclusions:

  • The relationship between CKD, PAD, and revascularization is complex.
  • CKD patients with PAD require careful consideration due to heightened procedural risks.
  • Further research is crucial to optimize management strategies for this patient population.

Keywords:
CKDESKDPADalbuminuriaamputationschronic kidney diseaseperipheral artery disease

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