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Comparison of the cardiovascular presentations, complications and outcomes following different coronaviruses'
Mohammad Mostafa Ansari Ramandi1, Hossein Yarmohammadi2, Somayeh Beikmohammadi3
1Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Insights
Coronavirus infections, including COVID-19, SARS, and MERS, can cause cardiovascular issues. Cardiac injury was most common in COVID-19, while thrombotic issues were frequent in SARS, impacting disease severity and mortality.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2 (COVID-19), have emerged globally.
- Cardiovascular manifestations are increasingly recognized complications of these viral infections.
Purpose of the Study:
- To systematically review and synthesize the literature on cardiovascular manifestations associated with the coronavirus family.
- To compare the prevalence and impact of cardiovascular complications across different coronaviruses (COVID-19, SARS, MERS).
Main Methods:
- A systematic review adhering to PRISMA guidelines was conducted.
- Searches included PubMed, Scopus, Web of Science, Cochrane, ProQuest, Google Scholar, and reference lists.
- Keywords included "COVID-19", "SARS", "MERS", and "cardiovascular presentation".
Main Results:
- 28 original articles and 10 case studies were included, predominantly focusing on COVID-19.
- Cardiovascular presentations like acute cardiac injury, arrhythmias, and thrombotic complications were more prevalent in COVID-19.
- Cardiac injury predicted disease severity and mortality in both COVID-19 and SARS.
Conclusions:
- Coronaviruses, particularly COVID-19, can present with diverse cardiovascular manifestations.
- Cardiovascular complications are associated with worse outcomes in COVID-19 patients.
- Understanding these links is crucial for patient management and prognosis.
Abstract:
Manifestations caused by coronavirus family have presented it in many ways during the previous years. The aim of this systematic review was to gather all possible cardiovascular manifestations of the coronavirus family in the literature. Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Scopus, Web of Science, Cochrane and ProQuest which were updated on May 1, 2020 for the last time. Regarding to the novelty and speed of publications on COVID-19, we searched Google Scholar and also references of included studies and review articles in the systematic search results were searched manually. The searched keywords were the combination of the following MeSH terms: "COVID-19", "SARS", "MERS" and "cardiovascular presentation". The systematic review was registered with ID CRD42020180736 in International Prospective Register of Systematic Reviews (PROSPERO). After screening, 28 original articles and ten case studies (five case reports and five case series) were included. Most of the studies were focused on COVID-19 (20 original articles and four case studies) while the only studies about Middle East Respiratory Syndrome (MERS) were a case report and a case series. Almost all the cardiovascular presentations and complications including acute cardiac injury, arrhythmias and the thrombotic complications were more prevalent in COVID-19 than severe acute respiratory syndrome (SARS) and MERS. The cardiac injury was the most common cardiovascular presentation and complication in COVID-19 whereas thrombotic complications were commonly reported in SARS. The cardiac injury was the predictor of disease severity and mortality in both COVID-19 and SARS.Coronavirus 2019 may present with cardiovascular manifestations and complications in signs and symptoms, laboratory data and other paraclinical findings. Also, cardiovascular complications in the course of COVID-19 may result in worse outcomes.
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