Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

785
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
785
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

458
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
458
Brain Imaging01:14

Brain Imaging

419
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
419
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.5K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.5K
Organization of the Brain01:30

Organization of the Brain

1.6K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of cognitive reserve with 9-year domain-specific cognitive trajectories and risk of cognitive impairment in Mexican older adults.

PloS one·2025
Same author

Normative Data for the Montreal Cognitive Assessment (MoCA) in Mexican Adults: A Regression-Based Approach.

Diagnostics (Basel, Switzerland)·2025
Same author

The Effect of Attentional Locus on Multisensory Congruence: An ERP Study.

Psychophysiology·2025
Same author

Compensatory cognitive training in the schizophrenia spectrum: A pilot study in an outpatient Mexican sample.

Applied neuropsychology. Adult·2025
Same author

Usability, sense of presence, and performance of a virtual reality emotion recognition task.

PloS one·2025
Same author

Electromagnetic field stimulation for long-term mobility assessment after sciatic nerve injury.

Neurological research·2025

Related Experiment Video

Updated: Oct 26, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.3K

Structural Brain Changes Associated with Overweight and Obesity.

Erick Gómez-Apo1, Alejandra Mondragón-Maya2, Martina Ferrari-Díaz2

  • 1Servicio de Anatomía Patológica, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Mexico.

Journal of Obesity
|July 30, 2021
PubMed
Summary

Obesity causes brain inflammation, leading to neurodegeneration and reduced gray matter volume. This highlights the need for interventions targeting obesity-related brain changes.

More Related Videos

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.2K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Related Experiment Videos

Last Updated: Oct 26, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.3K
Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.2K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Area of Science:

  • Neuroscience
  • Metabolic Health
  • Obesity Research

Background:

  • Obesity is a global health crisis linked to numerous comorbidities.
  • Overnutrition triggers hypothalamic inflammation, impacting brain health.
  • Neuroimaging and cell density studies reveal brain alterations in obesity.

Purpose of the Study:

  • To review recent findings on neuroinflammation and neurodegeneration in obesity.
  • To explore the role of overnutrition-induced hypothalamic inflammation.
  • To discuss cognitive impairments associated with obesity.

Main Methods:

  • Review of neuroimaging studies.
  • Analysis of cell density studies.
  • Examination of mechanisms linking obesity to neuroinflammation and neuronal loss.

Main Results:

  • Consistent evidence of reduced cortical thickness and gray matter volume in overweight/obese individuals.
  • Commonly affected brain regions include frontal, temporal, basal nuclei, and cerebellum.
  • Obesity-induced neuroinflammation involves cytokine/chemokine signaling, microglial activation, and potential microangiopathy.

Conclusions:

  • Obesity-induced neuroinflammation contributes to neurodegeneration and neuronal loss.
  • Mechanisms include inflammatory cytokine release and microangiopathy.
  • Effective prevention and treatment strategies for obesity-related brain changes are crucial.