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Updated: Oct 26, 2025

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
Published on: July 8, 2012
Hematopoietic stem and progenitor cells directly participate in host immune response
Olusola Jumoke Daramola1,2,3, Stephen Osasan4, Hebah Ali5,6
1Department of Histopathology, University of Wirral Teaching Hospital NHS Trust Arrowe Park Wirral CH49 5PE, UK.
Abstract:
The properties of hematopoietic stem and progenitor cells (HSPCs), including self-renewal and pluripotency, have been extensively studied. These features have been explored in the management of several haematological disorders and malignancies. Although their role as precursors of innate immune cells is well understood, little is known about their direct participation in host immune response. In this review, we explicate the direct role of HSPCs in the host immune response and highlight therapeutic options for the infectious disease burden that is currently ravaging the world, including COVID-19.
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