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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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A Retrospective Observational Study: Is Absolute Lymphocyte Count a Prognostic Marker in COVID-19?

Mansoor Zafar1, Muhammad Shahbaz2, Mangala Karkhanis2

  • 1Gastroenterology and General Internal Medicine, Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-on-Sea, GBR.

Cureus
|July 30, 2021
PubMed
Summary

Low absolute lymphocyte count was linked to COVID-19 mortality in initial analysis. However, this association disappeared after accounting for patient comorbidities, suggesting comorbidities are a key factor in COVID-19 outcomes.

Keywords:
alcohol-related liver diseasecopd: chronic obstructive pulmonary diseasecovid-19firth logistic regression models for mortalitylasso modellymphocyte countrestricted cubic splinessevere acute respiratory syndrome coronavirus-2 (sars-cov-2)stata version 16 (statacorp texas)treat as positive (tap)

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Area of Science:

  • * Infectious Diseases
  • * Hematology
  • * Epidemiology

Background:

  • * The COVID-19 pandemic caused by SARS-CoV-2 has led to significant global mortality.
  • * Absolute lymphocyte count (ALC) has been investigated as a potential prognostic marker for COVID-19 outcomes.
  • * The influence of comorbidities on the relationship between ALC and COVID-19 mortality requires further clarification.

Purpose of the Study:

  • * To investigate the correlation between low absolute lymphocyte count and COVID-19-related mortality.
  • * To analyze the impact of comorbidities on this potential association.

Main Methods:

  • * Retrospective observational cohort study.
  • * Analysis of 742 patients tested for COVID-19 with measured blood lymphocyte levels.
  • * Assessment of 30-day survival, mortality, and comorbidities.

Main Results:

  • * No significant difference in lymphocyte count between COVID-19 positive and negative patients.
  • * Significantly lower lymphocyte counts observed in patients who died from COVID-19 (p < 0.001).
  • * An increased number of comorbidities was associated with a significantly decreased lymphocyte count.

Conclusions:

  • * While low lymphocyte count showed an initial association with COVID-19 mortality, this link was not significant after adjusting for comorbidities.
  • * Comorbidities play a crucial role in the relationship between lymphocyte count and COVID-19 outcomes.
  • * Absolute lymphocyte count alone, without considering comorbidities, may not be a reliable predictor of COVID-19 mortality.