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Managing Hypertension in the elderly: What's new?
1Departments of Medicine and Cardiology, Westchester Medical Center and New York Medical College, Macy Pavilion, Room 141, 10595, Valhalla, NY, USA.
Insights
Hypertension management in older adults requires personalized care. Clinical judgment is key for frail elderly patients, but more trials are needed for this population.
Area of Science:
- Cardiology
- Geriatrics
- Clinical Pharmacology
Background:
- Hypertension is a leading modifiable risk factor for cardiovascular disease and mortality globally.
- In the elderly, hypertension significantly increases cardiovascular event risk.
- The 2017 ACC/AHA guidelines recommend treating systolic blood pressure (SBP) <130 mmHg in adults aged 65+.
Purpose of the Study:
- To review current recommendations for hypertension management in the elderly.
- To highlight the need for tailored treatment strategies in frail elderly individuals.
- To identify gaps in clinical trial data for specific elderly subpopulations.
Main Methods:
- Review of the 2017 ACC/AHA hypertension guidelines.
- Discussion of clinical considerations for managing hypertension in elderly patients with comorbidities.
- Identification of areas requiring further research, particularly in frail and older populations.
Main Results:
- Current guidelines recommend SBP <130 mmHg for community-dwelling elderly.
- Clinical judgment and patient-centered approaches are crucial for frail elderly with comorbidities and limited life expectancy.
- Significant gaps exist in evidence for hypertension treatment in nursing home residents, those over 85, and frail individuals.
Conclusions:
- Personalized treatment decisions are essential for elderly hypertensive patients, balancing benefits and risks.
- Randomized clinical trials are urgently needed in frail elderly populations, including nursing home residents and those with multiple comorbidities.
- Further research should investigate the impact of various antihypertensive drugs on clinical outcomes and adverse events in diverse elderly groups.
Abstract:
Hypertension is the leading modifiable risk factor for cardiovascular events and mortality in the world. Hypertension is a major risk factor for cardiovascular events and mortality in the elderly. The 2017 American College of Cardiology/American Heart Association hypertension guidelines recommend treatment of noninstitutionalized ambulatory community-dwelling persons aged 65 years and older with an average systolic blood pressure of 130 mm Hg or higher or a diastolic blood pressure of 80 mm Hg or higher with lifestyle measures plus antihypertensive drug to lower the blood pressure to less than 130/80 mm Hg For elderly adults with hypertension and a high burden of comorbidities and limited life expectancy, clinical judgment, patient preference, and a team-based approach to assess risk/benefit is reasonable for decisions about the intensity of SBP lowering and the choice of antihypertensive drugs to use for treatment. Randomized clinical trials need to be performed in frail elderly patients with hypertension living in nursing homes. Elderly frail persons with prevalent and frequent falls, marked cognitive impairment, and multiple comorbidities requiring multiple antihypertensive drugs also need to be included in randomized clinical trials. Data on patients older than 85 years treated for hypertension are also sparse. These patients need clinical trial data. Finally, the effect of different antihypertensive drugs on clinical outcomes including serious adverse events needs to be investigated in elderly frail patients with hypertension and different comorbidities.
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