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Natural Polymeric Scaffolds for Tissue Engineering Applications.

Samuel Ogbeide Ebhodaghe1

  • 1Department of Chemical Engineering, University of Benin, Benin City, Nigeria.

Journal of Biomaterials Science. Polymer Edition
|July 30, 2021
PubMed
Summary

Natural polymeric scaffolds offer biocompatibility and tunable properties for tissue engineering. This review covers their development for cartilage, cornea, osteochondral, and nerve regeneration applications, guiding future research.

Keywords:
Tissue engineeringbiomaterialsclinical applicationsnatural biopolymer scaffoldsregenerative medicine

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Natural polymeric scaffolds possess advantageous properties like biocompatibility, tunable mechanical strength, conductivity, large surface area, and extracellular matrix (ECM)-mimicked structures.
  • Their low toxicity and biocompatibility make them ideal for various tissue engineering applications.
  • While research exists on nanocomposite biopolymers, a comprehensive review of their tissue engineering applications is needed.

Purpose of the Study:

  • To comprehensively review the development and application of natural biopolymers as scaffolds in tissue engineering.
  • To highlight specific applications including cartilage tissue engineering, cornea repairs, osteochondral defect repairs, and nerve regeneration.
  • To present implications of findings for future research and provide recommendations.

Main Methods:

  • Literature review of natural biopolymers used as scaffolds in tissue engineering.
  • Analysis of the properties and development of common natural biopolymers for regenerative medicine.
  • Synthesis of information on applications in cartilage, cornea, osteochondral, and nerve regeneration.

Main Results:

  • Natural biopolymers are effective scaffolds due to their inherent biocompatibility and tunable properties.
  • These materials show promise in diverse tissue engineering applications, including cartilage, cornea, osteochondral, and nerve regeneration.
  • The review consolidates current knowledge and identifies areas for future investigation.

Conclusions:

  • Natural polymeric scaffolds are versatile and highly suitable for a range of tissue engineering applications.
  • Further research into natural biopolymers can advance regenerative medicine and therapeutic strategies.
  • This review provides a foundation for future studies and development in the field.