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Updated: Oct 26, 2025
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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
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Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer
Yohei Iimura1, Tomohiro Kurokawa2, Shohei Andoh3
1Departmentof Pharmacy, The IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Summary
Thiamine deficiency is linked to neuropsychiatric symptoms in cancer patients. Chemotherapy can lower thiamine levels, increasing the risk of these symptoms, especially in hematological cancer patients.
Area of Science:
- Oncology
- Neurology
- Nutritional Science
Background:
- Limited clinical data exists on early-stage thiamine-related neuropsychiatric symptoms.
- Serum thiamine levels are often tested only in severe deficiency cases.
Purpose of the Study:
- To investigate the link between thiamine decline and neuropsychiatric symptoms in cancer patients undergoing chemotherapy.
- To assess the impact of chemotherapy on serum thiamine levels.
Main Methods:
- Retrospective analysis of 87 gastrointestinal and hematological cancer patients.
- Evaluation of risk factors for neuropsychiatric symptoms and serum thiamine levels.
- Assessment of changes in serum thiamine levels post-chemotherapy.
Main Results:
- Thiamine decline was a significant risk factor for neuropsychiatric symptoms (OR=0.040, p<0.001).
- Patients with neuropsychiatric symptoms had lower serum thiamine levels (19.5 ng/mL vs. 31.9 ng/mL, p=0.001).
- Hematological cancer patients showed declining thiamine levels post-chemotherapy, reaching lowest levels at 5-8 weeks.
Conclusions:
- Decreased serum thiamine levels are a risk factor for neuropsychiatric symptoms.
- Chemotherapy contributes to reduced serum thiamine levels in cancer patients.
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