Interplay between nanomedicine and protein corona

Area of Science:

• Biomedical Engineering
• Materials Science
• Pharmacology

Background:

• Nanomedicine holds promise for various biomedical applications.
• Clinical translation of nanomedicine is hindered by safety and efficiency concerns.
• The protein corona (PC) forms on nanoparticles in biological fluids, influencing their behavior.

Purpose of the Study:

• To review the factors influencing protein corona formation.
• To explore nanomedicine applications by modulating the nanomedicine-protein corona interplay.
• To enhance the clinical utility of nanomedicines.

Main Methods:

• Literature review of studies on nanomedicine-protein corona interactions.
• Analysis of factors affecting protein corona composition.
• Synthesis of current understanding of nanomedicine properties and biological environment influences.

Main Results:

• Protein corona composition is determined by nanomedicine physical properties (size, shape, surface) and the biological milieu.
• The protein corona dictates nanomedicine's biological identity and function.
• Abundant research has elucidated factors influencing protein corona formation.

Conclusions:

• Understanding and regulating the nanomedicine-protein corona interaction is crucial for optimizing nanomedicine performance.
• Tailoring nanomedicine design based on protein corona knowledge can improve clinical safety and efficacy.
• Further research into protein corona modulation strategies is warranted for advanced nanomedicine development.