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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Disease Burden Affects Aging Brain Function.

Lori L Beason-Held1, Danielle Fournier1, Andrea T Shafer1

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The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|July 30, 2021
PubMed
Summary
This summary is machine-generated.

Older adults with multiple chronic diseases show altered brain activity in key regions. This study links disease burden to changes in brain function in aging individuals.

Keywords:
Brain activityHealthImagingMRIPET

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Most older adults experience multiple chronic diseases.
  • The impact of multimorbidity on brain function is not well understood.

Purpose of the Study:

  • To investigate the relationship between disease multimorbidity and brain activity.
  • To identify specific brain regions affected by multiple health conditions in older adults.

Main Methods:

  • Used 15O-water PET scans to measure regional cerebral blood flow (rCBF) in 97 cognitively normal older adults.
  • Calculated multimorbidity index scores based on 13 health conditions.
  • Correlated multimorbidity with baseline and longitudinal changes in rCBF over approximately 5 years.

Main Results:

  • Higher multimorbidity was linked to reduced activity in frontal and temporal regions, and increased activity in temporal, occipital, and cerebellar areas at baseline.
  • Hypertension and chronic kidney disease were significant individual contributors to altered brain activity.
  • Longitudinal analysis revealed widespread changes in brain activity (both increases and decreases) associated with increasing multimorbidity over time.

Conclusions:

  • Greater disease multimorbidity is associated with widespread alterations in brain activity in older adults.
  • These findings support a connection between overall health status and age-related changes in brain function.