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Updated: Oct 26, 2025
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Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
Published on: March 5, 2022
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Regulatory effect of m6 A modification on different viruses
Pei-Lun Yu1, San-Jie Cao1, Rui Wu1
1Department of Preventive Veterinary Medicine, Swine Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, PR China.
Journal of Medical Virology
|July 30, 2021
Summary
N6-methyladenosine (m6A) modification, a key RNA process, impacts viral replication and host immunity. This review explores its dual regulatory roles across various viruses, offering insights into epitranscriptomic regulation.
Area of Science:
- Molecular Biology
- Virology
- Epigenetics
Background:
- N6-methyladenosine (m6A) is the most prevalent reversible RNA modification in eukaryotes.
- m6A regulation involves methyltransferases, demethylases, and binding proteins.
- Viral replication and host immune responses are influenced by m6A.
Purpose of the Study:
- To review the regulatory effects of m6A modification on diverse viruses.
- To provide a reference for understanding RNA epitranscriptomic modification in viral contexts.
Main Methods:
- Literature review of studies on m6A modification and viral interactions.
- Analysis of the dual regulatory functions of m6A in different viral systems.
Main Results:
- m6A modification exhibits opposing regulatory roles in viral replication and pathogenesis.
- The impact of m6A varies significantly across different types of viruses.
Conclusions:
- m6A epitranscriptomic modification plays a complex and often contradictory role in virus-host interactions.
- Further research into m6A is crucial for understanding viral dynamics and developing antiviral strategies.
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