Cyclodextrin based bone regenerative inclusion complex for resveratrol in postmenopausal osteoporosis
Aarti Abhishek Shah1, Abhishek Shah2, Shaila Lewis3
1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka 576104, India.
Summary
Resveratrol (RSV) inclusion complex with sulfo-butyl ether β-cyclodextrin (SBE-β-CD) enhances bioavailability for osteoporosis treatment. This safe and effective complex improves bone micro-architecture in ovariectomized rats.
Area of Science:
- Pharmacology
- Biomaterials Science
- Bone Biology
Background:
- Resveratrol (RSV) shows promise for osteoporosis due to anti-inflammatory and antioxidant effects.
- Poor oral bioavailability and systemic delivery limit RSV's therapeutic success.
- Developing effective delivery systems is crucial for harnessing RSV's potential.
Purpose of the Study:
- To create a sulfo-butyl ether β-cyclodextrin (SBE-β-CD) inclusion complex with resveratrol (RSV) to improve solubility and bioavailability.
- To evaluate the safety and efficacy of the RSV-SBE-β-CD inclusion complex (R-CDIC) in an ovariectomized (OVX) rat model of postmenopausal osteoporosis.
Main Methods:
- In-silico docking and physico-chemical characterization to study RSV-SBE-β-CD interaction.
- In vivo safety assessment in Wistar rats.
- Efficacy evaluation in OVX rats using microcomputed tomographic scanning, serum biochemical analysis, biomechanical testing, and histopathology.
Main Results:
- The RSV-SBE-β-CD inclusion complex (R-CDIC) was found to be safe in Wistar rats.
- R-CDIC significantly ameliorated bone micro-architectural deterioration in OVX rats.
- Bone morphometry and biomechanical studies confirmed the efficacy of R-CDIC in improving bone health.
Conclusions:
- The RSV-SBE-β-CD inclusion complex effectively enhances resveratrol's therapeutic potential for osteoporosis.
- This formulation represents a promising strategy for treating osteolytic degradation associated with estrogen deficiency.
- Improved solubility and delivery of RSV via SBE-β-CD overcome previous limitations, offering a viable treatment option.
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