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[Apoprotein E (apo E) phenotype and serum lipids in diabetics]
R W James1, C Voliotis, B Grab
1Division de diabétologie, Hôpital cantonal universitaire, Genève.
Schweizerische Medizinische Wochenschrift
|December 12, 1987
Summary
Apolipoprotein E (Apo E) isoforms do not differ in diabetics versus controls. However, the Apo E epsilon 2 allele is linked to higher triglycerides and cholesterol in diabetic patients.
Area of Science:
- Biochemistry
- Genetics
- Metabolic Disorders
Context:
- Diabetes mellitus is a metabolic disorder associated with dyslipidemia.
- Apolipoprotein E (Apo E) is a key protein in lipid metabolism.
- Understanding the role of Apo E isoforms in diabetic dyslipidemia is crucial.
Purpose:
- To investigate the distribution of apolipoprotein E (Apo E) isoforms in a diabetic population.
- To examine the association between specific Apo E phenotypes and serum lipid levels in diabetics.
Summary:
- Allele frequencies for Apo E epsilon 2, epsilon 3, and epsilon 4 did not significantly differ between diabetic patients and a control population.
- Diabetics carrying the Apo E epsilon 2 allele exhibited elevated serum triglyceride levels compared to those with epsilon 3 or epsilon 4 alleles.
- Individuals with the E2/2 Apo E phenotype showed significantly higher levels of both serum cholesterol and triglycerides.
Impact:
- The findings indicate that apolipoprotein E phenotype influences serum lipid profiles in individuals with diabetes.
- This research highlights the potential of Apo E genotyping for personalized risk assessment and management of dyslipidemia in diabetics.