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Viral-Induced Inflammatory Coagulation Disorders: Preparing for Another Epidemic.
Toshiaki Iba1, Jerrold H Levy2, Marcel Levi3
1Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Thrombosis and Haemostasis
|July 31, 2021
Summary
Future pandemics of viral diseases like COVID-19 and viral hemorrhagic fevers are likely. Understanding viral coagulopathy and thromboinflammation is crucial for preparing effective treatments and interventions.
Area of Science:
- Virology
- Infectious Diseases
- Global Health
Background:
- Emerging and re-emerging viral infectious diseases pose significant global health threats.
- Increased travel, commerce, and climate change facilitate the rapid spread of viral diseases.
- The COVID-19 pandemic highlighted the potential for widespread viral outbreaks, with future pandemics being probable.
Purpose of the Study:
- To review the coagulopathy associated with acute viral infections.
- To compare the hypercoagulable state in COVID-19 with that in viral hemorrhagic fevers.
- To emphasize the importance of anticoagulation in managing viral infections.
Main Methods:
- Literature review focusing on viral coagulopathy.
- Comparative analysis of hypercoagulability in COVID-19 and viral hemorrhagic fevers.
- Discussion of thromboinflammation mechanisms in viral infections.
Main Results:
- Coagulation disorders are a key link between COVID-19 and viral hemorrhagic fevers.
- COVID-19 presents with hypercoagulability, distinct from the presentation in viral hemorrhagic fevers.
- Both conditions involve thromboinflammation, necessitating consideration of anticoagulation strategies.
Conclusions:
- Preparation for future viral pandemics is essential, drawing lessons from COVID-19.
- Understanding viral-induced coagulopathy is critical for developing therapeutic interventions.
- Anticoagulation plays a vital role in managing the complications of acute viral infections.
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