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Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction
Ginger Egberts1,2, Fred Vermolen3, Paul van Zuijlen4,5,6
1Delft Institute of Applied Mathematics, Delft University of Technology, Delft, The Netherlands. G.Egberts@tudelft.nl.
Biomechanics and Modeling in Mechanobiology
|July 31, 2021
Summary
This study models burn scar contraction, finding key parameters like collagen and cell activity significantly influence tissue changes. The model predicts distinct contraction densities across age groups but shows clinical discrepancies, especially in children and the elderly.
Area of Science:
- Biomedical Engineering
- Computational Biology
- Dermatology
Background:
- Burn scar contractures limit range of motion, affecting 58.6% at 3-6 weeks post-injury.
- Understanding scar contraction is crucial for effective treatment and rehabilitation.
Purpose of the Study:
- To develop and validate a one-dimensional morphoelastic model for post-burn scar contraction.
- To assess the model's ability to predict contraction extent in different age groups.
Main Methods:
- A one-dimensional morphoelastic model incorporating dermal displacement, Eulerian strain, signaling molecules, fibroblasts, myofibroblasts, and collagen.
- Sensitivity analysis of model parameters.
- Literature review for parameter value acquisition.
Main Results:
- Equilibrium collagen concentration, fibroblast/myofibroblast apoptosis rate, and signaling molecule secretion rate are the most sensitive parameters.
- The model simulates distinct contraction densities across age groups.
- Simulated results show discrepancies with clinical observations, particularly in pediatric and geriatric populations.
Conclusions:
- The morphoelastic model provides insights into scar contraction mechanisms.
- Model predictions for pediatric and elderly populations require refinement to align with clinical realities, suggesting age-specific biological factors are critical.
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