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Application of quantitative systems pharmacology to guide the optimal dosing of COVID-19 vaccines

Mario Giorgi1, Rajat Desikan1, Piet H van der Graaf1

  • 1Certara QSP, Certara UK Limited, Sheffield, UK.

CPT: Pharmacometrics & Systems Pharmacology
|July 31, 2021
PubMed

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It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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