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Treadmill exercise overcomes memory deficits related to synaptic plasticity through modulating ionic glutamate

Baixia Li1, Qian Mao1, Na Zhao1

  • 1School of Physical Education and Health Care, East China Normal University, Shanghai, China; Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, China.

Behavioural Brain Research
|July 31, 2021
PubMed
Summary

Regular exercise in Alzheimer's disease (AD) models reduced beta-amyloid (Aβ) plaques and improved cognitive function. Exercise also enhanced synaptic plasticity and normalized glutamate receptor function, suggesting a therapeutic benefit for AD.

Keywords:
Alzheimer’s diseaseExerciseIonic glutamate receptorSynaptic plasticity

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