Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impaired tracheobronchial clearance in bronchiectasis.

D C Currie1, D Pavia, J E Agnew

  • 1Department of Thoracic Medicine, Brompton Hospital, London.

Thorax
|February 1, 1987
PubMed
Summary

Tracheobronchial clearance is significantly slower in patients with bronchiectasis and chronic obstructive lung disease (COPD) compared to healthy individuals. This impaired clearance is similar between bronchiectasis and COPD patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Sapienza University of Rome network of automated external defibrillators: a prototype webMap developed to speed access to community defibrillators and increase survival from out-of-hospital cardiac arrest.

European review for medical and pharmacological sciences·2023
Same author

Genetic panmixia within a narrow contact zone between chromosomally and ecologically distinct black fly sibling species (Diptera: Simuliidae).

Journal of evolutionary biology·2015
Same author

DNA barcoding distinguishes pest species of the black fly genus Cnephia (Diptera: Simuliidae).

Journal of medical entomology·2014
Same author

A comparison between monodisperse Tc-99m-labeled aerosol particles and Kr-81m for the assessment of lung function.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2013
Same author

Use of pressurized aerosol bronchodilators.

Journal of the Royal Society of Medicine·2010
Same author

A one-year trial of tiotropium Respimat plus usual therapy in COPD patients.

Respiratory medicine·2010

Area of Science:

  • Respiratory Medicine
  • Pulmonary Physiology
  • Medical Imaging

Background:

  • Tracheobronchial clearance is crucial for lung health, removing inhaled particles and pathogens.
  • Bronchiectasis and Chronic Obstructive Lung Disease (COPD) are conditions often associated with impaired airway clearance.
  • Understanding clearance mechanisms in these diseases is vital for effective management.

Purpose of the Study:

  • To compare tracheobronchial clearance in patients with bronchiectasis to those with COPD and healthy subjects.
  • To investigate the relationship between sputum production, cough, and clearance in these groups.
  • To assess the degree of clearance impairment in bronchiectasis relative to COPD.

Main Methods:

  • Radioaerosol technique used to measure tracheobronchial clearance over six hours.

Related Experiment Videos

  • Study included patients with bronchiectasis, COPD with mucoid sputum (Group X), COPD with negligible sputum (Group Y), and healthy controls.
  • Forced expiratory volume in one second (FEV1) and sputum weight were recorded; smoking status noted.

    • Main Results:

    • Tracheobronchial clearance was significantly slower (p < 0.01) in bronchiectasis patients versus healthy subjects.
    • Bronchiectasis patients exhibited more proximal radioaerosol deposition (p = 0.01) and increased coughing (p < 0.01).
    • Clearance impairment in bronchiectasis was comparable to that in COPD patients (Groups X and Y).

    Conclusions:

    • Tracheobronchial clearance is significantly impaired in patients with bronchiectasis.
    • The degree of clearance impairment in bronchiectasis is similar to that observed in COPD patients.
    • Radioaerosol clearance measurements provide valuable insights into airway clearance dysfunction in respiratory diseases.