Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary function in advanced pulmonary hypertension.

C M Burke1, A R Glanville, A J Morris

  • 1Division of Respiratory Medicine, Stanford University Medical Center, California.

Thorax
|February 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Prevalence of healthcare-associated infections in public hospitals in New Zealand, 2021.

The Journal of hospital infection·2022
Same author

Mental Disorders and Oral Diseases: Future Research Directions.

Journal of dental research·2022
Same author

Dental fluorosis.

British dental journal·2022
Same author

The effect of inner-sphere reorganization on charge separated state lifetimes at sensitized TiO<sub>2</sub> interfaces.

The Journal of chemical physics·2020
Same author

Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection.

Irish medical journal·2020
Same journal

Mediastinal amyloidosis mimicking advanced lung cancer.

Thorax·2026
Same journal

Comparative performance of endobronchial ultrasound-guided sampling techniques in patients with mediastinal lesions: a network meta-analysis.

Thorax·2026
Same journal

Vitamin A and D impact on lung function: differential or common effects across the lifespan?

Thorax·2026
Same journal

The impact of vitamins A and D on lung function and regulatory epigenetics in adult and childhood asthma.

Thorax·2026
Same journal

Radiological factors associated with the recurrence of <i>Mycobacterium avium complex</i> pulmonary disease: a multicentre retrospective cohort study.

Thorax·2026
Same journal

Daughter vesicles in primary diaphragmatic hydatid cyst.

Thorax·2026
See all related articles

Advanced pulmonary vascular disease, including primary pulmonary hypertension and Eisenmenger physiology, significantly impairs lung function and gas exchange, causing severe hypoxemia and altered pulmonary mechanics.

Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Research
  • Respiratory Physiology

Background:

  • Advanced pulmonary vascular disease (PVD) encompasses conditions like primary pulmonary hypertension (PPH) and Eisenmenger physiology.
  • These conditions significantly impact lung function and gas exchange, necessitating detailed investigation.

Purpose of the Study:

  • To investigate pulmonary mechanical function and gas exchange in patients with advanced PVD.
  • To compare these parameters between patients with PPH and Eisenmenger physiology.

Main Methods:

  • Studied 33 patients with advanced PVD (18 PPH, 15 Eisenmenger).
  • Assessed pulmonary mechanical function, including total lung capacity (TLC) and airflow obstruction.
  • Evaluated gas exchange, measuring transfer factor for carbon monoxide (TLCO) and arterial oxygen tension (PaO2).

Related Experiment Videos

Main Results:

  • Most patients exhibited evidence of airway obstruction.
  • Mean TLC was reduced to 81.5% of predicted, with 27% below one standard deviation.
  • Mean TLCO was 71.8% of predicted, with significant arterial hypoxemia disproportionate to mechanical changes.
  • Eisenmenger patients showed lower PaO2 and maximum mid-expiratory flow, and higher pulmonary arterial pressure compared to PPH patients.

Conclusions:

  • Advanced PVD, whether PPH or Eisenmenger physiology, is linked to severe hypoxemia.
  • Altered pulmonary mechanical function is a significant characteristic of these advanced PVD conditions.
  • Patients with Eisenmenger physiology present with more severe gas exchange impairment and higher pulmonary pressures.