An overview on plants cannabinoids endorsed with cardiovascular effects

Area of Science:

• Pharmacology
• Cardiovascular Medicine
• Natural Products Chemistry

Background:

• Cardiovascular diseases (CVDs) significantly reduce quality of life.
• The endocannabinoid system is a key target for cardiovascular disorders, influencing blood pressure, inflammation, and cardiac function.
• Dysregulation of cannabinoid signaling is linked to cardiotoxicity, shock, hypertension, and atherosclerosis.

Purpose of the Study:

• To review less-studied plants containing cannabinoid-like compounds.
• To investigate the potential of these phytocompounds in treating cardiovascular disorders.
• To explore natural alternatives for managing cardiovascular conditions.

Main Methods:

• Literature review of scientific databases.
• Identification of plants with cannabinoid-like compounds.
• Analysis of their interaction with the endocannabinoid system and cardiovascular effects.

Main Results:

• Cannabinoid signaling plays a crucial role in cardiovascular regulation.
• Various plants, beyond Cannabis sativa, possess compounds that interact with the endocannabinoid system.
• These phytocompounds show potential for managing hypertension, inflammation, and other cardiovascular issues.

Conclusions:

• Natural compounds offer promising therapeutic avenues for cardiovascular diseases.
• Further research into less-explored plant sources could yield novel cardiovascular treatments.
• Targeting the endocannabinoid system with plant-derived molecules presents a viable strategy for cardiovascular health.