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Perspectives on immunometabolism at the biomaterials interface.

Sabrina L Macias1, Benjamin G Keselowsky2

  • 1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.

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Biomaterials scientists can now engineer immune responses by understanding immune cell metabolism. This approach enhances biomaterial design by focusing on immune cell interactions and their metabolic needs for better effector functions.

Keywords:
BiomaterialsForeign body reactionImmune cellsImmune engineeringImmunometabolismMetabolism

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Cellular Metabolism

Background:

  • Engaging the immune system productively is a key challenge in biomaterials science.
  • Immune engineering provides a novel framework for biomaterial design, focusing on immune cell interactions to modulate effector functions.
  • Immune cell effector functions are closely tied to their metabolic requirements and programming.

Purpose of the Study:

  • To provide an overview of recent advances in biomaterial interaction with immune cells.
  • To explore the interrogation of immunometabolism in the context of biomaterials.
  • To identify future opportunities for the convergence of biomaterials science and immunometabolism.

Main Methods:

  • Review of current literature on biomaterial-immune cell interactions.
  • Analysis of recent discoveries in immunometabolism.
  • Highlighting key immune cell types: neutrophils, macrophages, dendritic cells, and T cells.

Main Results:

  • Recent advances demonstrate opportunities for biomaterials scientists in immune engineering.
  • Understanding immunometabolism offers new strategies for modulating immune cell effector functions.
  • The convergence of biomaterials and immunometabolism is crucial for developing next-generation biomaterials.

Conclusions:

  • Integrating biomaterial design with immunometabolism research is essential for advancing the field.
  • A forward-looking approach considering both biomaterial engagement and immunometabolism will drive innovation.
  • This interdisciplinary perspective is key to a new era of biomaterials with engineered immune interactions.