13 trisomy born to a mother treated with bromocriptine: incidental or not?

A case of 13 trisomy born to a mother treated with bromocriptine is described. She, 27 years old, was treated with bromocriptine (5 mg/day) as a galactorrhea amenorrhea syndrome with hyperprolactinemia (basal 34-122 ng/ml). After the treatment for about a month, disappearance of galactorrhea and occurrence of menstruation were observed. She became pregnant on the second ovulation. On the 34th week she got a male 13 trisomy (47, XY, +13) baby with premature delivery. The baby died 11 hr after his birth. After the first delivery, bromocriptine was readministered. Following the induced abortion on the second pregnancy, she borned a healthy baby on the third pregnancy in spite of taking bromocriptine. This case of 13 trisomy might be incidental. However, the effect of bromocriptine on chromosome should be further evaluated in detail.