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Degradable RGD-Functionalized 3D-Printed Scaffold Promotes Osteogenesis.

P-C Chang1,2,3,4, Z-J Lin1, H-T Luo2,3

  • 1Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei.

Journal of Dental Research
|August 2, 2021
PubMed
Summary
This summary is machine-generated.

This study developed an oxidized RGD-functionalized alginate matrix (RAM) with osteoid-like stiffness for maxillofacial regeneration. Oxidized RAM combined with a 3D-printed hydroxyapatite scaffold significantly enhanced bone formation and regeneration.

Keywords:
alginatesbone regenerationextracellular matrixprintingthree-dimensionaltissue scaffold

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Maxillofacial defect regeneration requires ideal microenvironments.
  • Scaffold design and extracellular matrix stiffness are key for osteogenesis.

Purpose of the Study:

  • To develop and evaluate a degradable, RGD-functionalized alginate matrix (RAM) with osteoid-like stiffness for maxillofacial regeneration.
  • To investigate the effect of oxidized RAM on bone marrow stem cell behavior and in vivo bone formation.

Main Methods:

  • Fabrication of a rigid 3D-printed hydroxyapatite scaffold using microextrusion.
  • Development of RAM by crosslinking alginate with calcium sulfate and accelerating degradation via sodium periodate oxidation.
  • Assessment of cell viability, migration, and osteogenic differentiation in vitro.
  • Evaluation of in vivo maxillofacial regeneration using nonoxidized and oxidized RAM.

Main Results:

  • RAM with osteoid-like stiffness improved bone marrow stem cell viability, migration, and osteogenic differentiation, particularly when oxidized.
  • Nonoxidized RAM upregulated osteogenic genes but limited bone ingrowth.
  • Oxidized RAM promoted collagen synthesis, angiogenesis, and osteogenesis, leading to robust bone formation and enhanced maxillofacial regeneration.

Conclusions:

  • Oxidized RAM with osteoid-like stiffness provides essential mechanical cues and an appropriate degradation profile for osteogenesis.
  • Combining 3D-printed hydroxyapatite scaffolds with oxidized RAM offers a promising strategy for maxillofacial regeneration.