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Factors Influencing the Serum Uric Acid in Gout with Cerebral Infarction
Yi Li1, Hongyi Yang1, Yao Tian1
1Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
Insights
Gout patients with coronary heart disease (CHD) and cerebral infarction (CI) show distinct clinical features. Factors influencing serum uric acid (sUA) levels differ, suggesting tailored gout management for young smokers with CI.
Area of Science:
- Rheumatology
- Cardiology
- Neurology
Background:
- Gout's link to cardiovascular disease is established, but differences between gout with cerebrovascular disease and cardiovascular disease are unclear.
- This study investigates clinical distinctions and factors affecting serum uric acid (sUA) in gout patients with cerebral infarction (CI) versus coronary heart disease (CHD).
Purpose of the Study:
- To compare clinical characteristics of gout with coronary heart disease (gout+CHD) and gout with cerebral infarction (gout+CI).
- To identify factors influencing serum uric acid (sUA) levels in gout+CI patients.
Main Methods:
- A cross-sectional study analyzed medical records of gout+CHD, gout+CI, and gout+CHD+CI patients (2016-2020).
- Data on demographics, comorbidities, medication use, and laboratory values were collected.
Main Results:
- Significant differences were observed in age, drinking habits, hypertension, diuretic/NSAID use, sUA, CRE, and blood glucose between gout+CHD and gout+CI groups.
- In gout+CI, sUA positively correlated with smoking, CRE, and TG, and negatively with age and gender.
- Multiple regression identified age, gender, smoking, CRE, and TG as significant factors affecting sUA in gout+CI.
Conclusions:
- Gout+CHD and gout+CI patients exhibit notable clinical differences, particularly in factors influencing sUA levels.
- Uric acid-lowering therapy may require enhanced focus in young, smoking gout+CI patients.
Background:
Although the relationship between gout and cardiovascular has been well demonstrated, there is little information about the difference between gout with cerebrovascular disease and cardiovascular disease. In this study, the differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study.
Method:
The patients from Jiangxi Provincial People's Hospital with gout+CHD, gout+CI, and gout with coronary heart disease and cerebral infarction (gout+CHD+CI) between 2016 and 2020 were included in this study, and the medical record data were collected and analyzed.
Results:
We observed significant differences in age, drinking, hypertension, long-term use of diuretics and NSAIDs, sUA, CRE, and blood glucose in patients with gout+CHD and gout+CI. The sUA level was significantly positively correlated with smoking, CRE, and TG in the gout+CI group and was only positively correlated with CRE in the gout+CHD group and the gout+CHD+CI group (p < 0.05). Interestingly, the sUA level was only negatively correlated with the age and gender in the gout+CI group (p < 0.05). After excluding factors with no significant statistical effect, only age, gender, smoking, CRE, and TG were included in the multiple linear regression model. It suggested that smoking, CRE, and TG are positively correlated with the sUA level, while age was negatively correlated with the sUA level.
Conclusions:
There are many discrepancies in clinical characteristics between gout+CHD patients and gout+CI patients, especially that the factors that affect UA levels are significantly different. The data also suggested that uric acid-lowering therapy may need to be strengthened in the young gout+CI patients with a history of smoking.
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