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Gout Augments the Risk of Cardiovascular Disease in Patients With Psoriasis: A Population-Based Cohort Study

Zhiyong Chen1, Yiwen Xu1, Miao Chen1

  • 1Department of Rheumatology and Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Frontiers in Immunology
|August 2, 2021
PubMed

Insights

Gout significantly increases cardiovascular disease (CVD) risk in psoriasis (PsO) patients, independent of other factors. This highlights the need for integrated management of these conditions to mitigate CVD.

Area of Science:

  • Rheumatology
  • Cardiology
  • Dermatology

Background:

  • Psoriasis (PsO) is frequently associated with gout and an elevated risk of cardiovascular diseases (CVD).
  • The combined impact of PsO and gout on CVD risk requires further investigation.

Purpose of the Study:

  • To evaluate the synergistic effect of gout on the risk of developing CVD in patients with PsO.
  • To quantify the independent contribution of gout to CVD risk in PsO patients.

Main Methods:

  • A population-based cohort study using Taiwan's National Health Insurance Research Database (2000-2013).
  • Propensity score matching (1:4 ratio) for age and gender.
  • Cox proportional hazard models and Kaplan-Meier analysis to assess CVD risk.

Main Results:

  • Patients with combined PsO and gout showed a 2.39-fold higher risk of CVD compared to PsO alone.
  • After adjusting for traditional risk factors, gout alone increased CVD risk (HR 2.16), and combined PsO and gout further elevated it (HR 2.72).

Conclusions:

  • Gout acts as an independent risk factor for cardiovascular diseases in patients with psoriasis.
  • These findings underscore the critical interplay between PsO, gout, and CVD, necessitating comprehensive patient management strategies.
Abstract

Keywords:
cardiovascular diseaseepidemiologygoutpopulation based cohort studypsoriasis

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