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Updated: Oct 26, 2025
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
The Emerging Role of the Interactions between Circular RNAs and RNA-binding Proteins in Common Human Cancers
Meng-Ping Jiang1, Wen-Xiu Xu1, Jun-Chen Hou1
1Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Abstract:
Circular RNAs (circRNAs) are a unique family of noncoding RNAs that could regulate multiple biological processes, which play a crucial role in carcinogenesis, progression and chemotherapy resistance of cancers. Growing studies have demonstrated that circRNAs act as novel biomarkers and therapeutic targets for cancers by sponging microRNAs (miRNAs). Up to date, another function of circRNAs, combining with RNA-binding proteins (RBPs), was uncovered. However, there is limit studies illustrating the underlying mechanism of circRNAs-RBPs interactions, as well as showing its roles in diverse types of cancers. In this review, we collected the biogenesis, properties of circRNAs, and then synthesize the connection between circRNAs and RBPs, and try to clarify its molecular mechanisms involving in the pathogenesis and progression of several common cancers, aiming to provide a brand-new insight to the prognosis and treatment strategy for cancers.
Insights
Circular RNAs (circRNAs) regulate cancer by interacting with RNA-binding proteins (RBPs). This review explores circRNA-RBP mechanisms in cancer, offering new insights for prognosis and treatment.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are noncoding RNAs involved in biological processes.
- circRNAs play roles in cancer development, progression, and chemotherapy resistance.
- circRNAs can act as biomarkers and therapeutic targets by sponging microRNAs (miRNAs).
Purpose of the Study:
- To review the biogenesis and properties of circRNAs.
- To synthesize the interactions between circRNAs and RNA-binding proteins (RBPs).
- To clarify the molecular mechanisms of circRNA-RBP interactions in various cancers for improved prognosis and treatment strategies.
Main Methods:
- Literature review of circRNA biogenesis and properties.
- Synthesis of studies on circRNA-RBP interactions.
- Analysis of molecular mechanisms in cancer pathogenesis.
Main Results:
- circRNAs have diverse functions beyond miRNA sponging, including RBP binding.
- circRNA-RBP interactions are implicated in the pathogenesis and progression of several common cancers.
- Limited studies currently illustrate the detailed mechanisms of these interactions.
Conclusions:
- circRNA-RBP interactions represent a novel area for cancer research.
- Understanding these mechanisms can provide new insights into cancer prognosis.
- Targeting circRNA-RBP interactions may offer novel therapeutic strategies for cancer treatment.
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