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Related Experiment Video

Updated: Oct 26, 2025

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
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3D bioprinting in cardiac tissue engineering.

Zihan Wang1,2, Ling Wang3, Ting Li1

  • 1Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Theranostics
|August 2, 2021
PubMed
Summary

Cardiac tissue engineering (CTE) uses 3D bioprinting to create functional heart tissues. This review highlights advancements in bioinks, strategies, and applications for repairing myocardial deficiency.

Keywords:
3D bioprintingbioinkscardiac muscleprinted biomaterialstissue engineering

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Last Updated: Oct 26, 2025

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Heart disease remains a leading global cause of mortality, with myocardial damage being irreversible.
  • Cardiac tissue engineering (CTE) offers a promising therapeutic strategy for heart repair and disease modeling.
  • Traditional CTE methods face limitations in replicating complex cardiac structures.

Purpose of the Study:

  • To review recent advancements in 3D bioprinting for cardiac tissue engineering (CTE).
  • To discuss various 3D bioprinting strategies, bioink formulations, and composite bioinks.
  • To summarize applications of 3D bioprinting in creating cardiac patches, muscle, and bionic structures.

Main Methods:

  • Overview of conventional CTE approaches.
  • Detailed discussion of current 3D printing strategies and technologies.
  • Exploration of diverse bioink compositions and composite bioink strategies.

Main Results:

  • Significant progress in 3D bioprinting for fabricating complex cardiac constructs.
  • Development of advanced bioink formulations enabling cell integration and structural integrity.
  • Successful application of 3D bioprinting in creating functional cardiac patches and engineered muscle.

Conclusions:

  • 3D bioprinting is a powerful tool revolutionizing cardiac tissue engineering.
  • Addressing current challenges in 3D bioprinting is crucial for clinical translation.
  • Future perspectives highlight the potential of advanced bioprinting techniques in CTE.