Challenges in management of benign bone tumours complicated by pathological fracture in paediatric population

Optimum treatment of pathological fractures following benign bone tumours in paediatric population is controversial. The usual difficulties encountered while dealing such cases is to establish a correct pre-operative diagnosis and to choose between conservative vs operative management. The aim of the work is to highlight the difficult aspects of diagnosis and management of pathological fractures following benign bone tumours in paediatric population.

All paediatric patients (<18 years) with pathological fractures following benign bone tumours were included. Pathological fractures due to infection, metabolic bone diseases and malignant bone tumours were excluded. Initial pre-operative diagnosis was based on clinico-radiological characteristics of the tumour and FNAC/needle biopsy, while final diagnosis was confirmed with post-operative histology. Primary outcome measure was determination of any disparity between pre-operative diagnosis and final post-operative histological diagnosis and the need of a separate open biopsy procedure for establishing the exact nature of lesion. Secondary outcome measures were determination of complications following surgery, functional grade and any recurrence at latest follow-up at 3 years.

Out of 13 patients enrolled for the study, twelve patients met the inclusion criteria. Female to male quotient was 3:1, with average age of 12.17 years. We were able to make correct pre-operative diagnosis in 10 patients (83.3%) with systematic clinico-radiological analysis and carefully performed FNAC/needle biopsy. Disparity between pre-operative and final post-operative diagnosis was seen in two patients. In one of these two patients, initial pre-operative diagnosis was fibrous dysplasia, which turned out to be ossifying fibroma on final post-operative biopsy. While the other patient required an open biopsy to establish the nature of underlying pathology, as the pre-op histological evaluation revealed equivocal nature of bone lesion. Secondary outcome measures showed superficial infection in one, coxa vara in one, limb length discrepancy in 2 and fibular graft donor site morbidity in two. None of the patient had developed recurrence. All patients had complete healing of the fracture and lesion.

A thorough clinico-radiological analysis and carefully performed FNAC/needle biopsy can establish a correct pre-operative diagnosis in majority of patients with benign bone tumours complicated by pathological fracture. This approach will avoid preventable delay in the definitive treatment of such patients, and also preclude the need of a separate operation prior to definitive management. In sight of the findings of our study along with existing literature we propose for definitive treatment in straight-forward cases and pre-treatment biopsy in cases with inconclusive FNAC/needle biopsy results and lesions with suspicion of malignancy. Proper diagnostic evaluation and differentiation of benign pathological fractures from malignant counterparts followed by extended curettage or excision of lesion and biological reconstruction with or without osteosynthesis represents a feasible approach for managing such fractures.