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Acute Appendicitis Associated With Multisystem Inflammatory Syndrome in Children
Meghan E Hofto1, Erinn O Schmit1, Meenu Sharma1
1Pediatrics, Division of Pediatric Hospital Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, USA.
Cureus
|August 2, 2021
Summary
Multisystem inflammatory syndrome in children (MIS-C) can cause gastrointestinal issues. This case series highlights four children with MIS-C who also had acute appendicitis, suggesting a link between SARS-CoV-2 infection and appendicitis.
Area of Science:
- Pediatric infectious diseases
- Gastroenterology
- Cardiology
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition linked to SARS-CoV-2 infection.
- Gastrointestinal symptoms are frequently observed in MIS-C patients.
- Acute appendicitis is a common surgical emergency in children.
Observation:
- This case series describes four pediatric patients diagnosed with MIS-C.
- All four patients presented with symptoms suggestive of acute appendicitis.
- Diagnostic workup confirmed acute appendicitis in all observed cases.
Findings:
- The study documents a co-occurrence of MIS-C and acute appendicitis in four children.
- This observation strengthens the potential association between SARS-CoV-2 infection, MIS-C, and the development of acute appendicitis.
- The findings suggest appendicitis may be an underrecognized manifestation of MIS-C.
Implications:
- Pediatricians and surgeons should consider MIS-C in children presenting with acute appendicitis, especially during SARS-CoV-2 outbreaks.
- Early recognition and appropriate management are crucial for favorable outcomes in these complex cases.
- Further research is warranted to elucidate the pathophysiological mechanisms linking MIS-C and appendicitis.
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