Primary Diffuse Large B-Cell Lymphoma of the Urinary Tract: A Population-Based Analysis

Area of Science:

• Oncology
• Hematology
• Epidemiology

Background:

• Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin's lymphoma.
• Primary DLBCL of the urinary tract (UT) is rare, with limited understanding of its clinical features and prognosis.

Purpose of the Study:

• To investigate the clinical characteristics of UT-DLBCL.
• To identify independent prognostic factors for survival in patients with UT-DLBCL using the SEER database.

Main Methods:

• Retrospective analysis of the SEER database (1975-2016) for UT-DLBCL cases.
• Collected data on demographics, tumor stage, and treatments (surgery, radiation, chemotherapy).
• Utilized Kaplan-Meier curves to analyze overall survival (OS) and disease-specific survival (DSS).

Main Results:

• Analyzed 489 patients; median age was 69.
• Most UT-DLBCL cases originated from the kidney (72.39%) and bladder (24.95%).
• Surgical resection and chemotherapy significantly improved OS and DSS. Patients over 75 and Stage IV DLBCL had worse outcomes.

Conclusions:

• This is the largest population-based study on UT-DLBCL.
• Advanced age, male gender, lack of surgery or chemotherapy, and Stage IV disease are poor prognostic factors for UT-DLBCL.