Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications

Area of Science:

• Neuro-oncology
• Pathology
• Surgical Oncology

Background:

• Progesterone receptor (PR) expression is a known prognostic factor in meningiomas.
• Limited data exists on PR expression's correlation with patient age, tumor location, and recurrence patterns.

Purpose of the Study:

• To investigate the correlation between PR expression and clinical-pathological factors in meningiomas.
• To analyze the relationship between PR expression and recurrence rates, patterns, and time to recurrence.

Main Methods:

• Retrospective analysis of 300 meningioma cases.
• Classification of PR expression into five categories (absent to high).
• Correlation analysis with patient demographics, tumor characteristics, and recurrence data.

Main Results:

• Higher PR expression observed in medial skull base and spinal meningiomas.
• Inverse correlation between PR expression, WHO grade, and Ki-67 MIB1.
• Lower PR expression in recurrent meningiomas; higher PR expression associated with recurrence >5 years.

Conclusions:

• PR expression is a significant prognostic marker for meningioma recurrence time.
• PR expression does not differ between pre/postmenopausal women or recurrence patterns.
• Routine inclusion of PR assessment in meningioma pathology is recommended for prognostic evaluation.