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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Hypoxia-Induced Mitogenic Factor: A Multifunctional Protein Involved in Health and Disease

Moyang Lv1, Wenjuan Liu2

  • 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Frontiers in Cell and Developmental Biology
|August 2, 2021
PubMed

Insights

Hypoxia-induced mitogenic factor (HIMF) is crucial in physiological processes and diseases like pulmonary and metabolic disorders. This review covers HIMF

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Hypoxia-induced mitogenic factor (HIMF), also known as resistin-like molecule α (RELMα) or found in inflammatory zone 1 (FIZZ1), is a protein family member expressed in mice.
  • HIMF participates in vital physiological functions, including mitogenesis, angiogenesis, inflammation, and vasoconstriction.

Purpose of the Study:

  • To review the molecular characteristics of HIMF.
  • To summarize the physiological and pathological roles of HIMF in normal and diseased states.
  • To discuss the potential clinical significance for humans.

Main Methods:

  • Literature review of HIMF.
  • Analysis of molecular characteristics.
  • Synthesis of physiological and pathological data.

Main Results:

  • HIMF expression is stimulated under pathological conditions.
  • HIMF plays a critical role in pulmonary, cardiovascular, and metabolic disorders.
  • The review consolidates information on HIMF's functions and implications.

Conclusions:

  • HIMF is a significant factor in various biological processes.
  • Dysregulation of HIMF is linked to several human diseases.
  • Further research into HIMF could offer clinical insights.
Keywords:
angiogenesishypoxia-induced mitogenic factormitogenesisproinflammationvasoconstriction

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