Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Caspases01:24

Caspases

12.9K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.9K
Apoptosis01:30

Apoptosis

12.4K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
12.4K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

7.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
7.1K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.9K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.9K
Overview of Cell Death01:30

Overview of Cell Death

8.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
8.1K
Autophagic Cell Death01:18

Autophagic Cell Death

3.7K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-guided discovery of antibiotic activity in <i>Streptomyces virginiae</i> THA-960 against multidrug resistant <i>Staphylococcus aureus</i>.

iScience·2026
Same author

Lacticaseibacillus parahuelsenbergensis THGS-36 alleviates acne-like inflammation and lipogenesis in sebocytes via CREB signaling.

Life sciences·2026
Same author

Dose-dependent biphasic effect of environmental UVA on stem cell function through PRPF40A, TGF-β1, NFATc1 signaling.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

Lactilactobacillus curvatus TH19-7: a broad-spectrum antimicrobial probiotic targeting skin pathogens and mitigating infection-associated dermal damage in vitro.

Archives of microbiology·2026
Same author

Effects of nutritive and non-nutritive sweeteners on acne vulgaris: A systematic review.

Fitoterapia·2025
Same author

Apoptosis Induction and MAPK Pathway Modulation by Lagerstroemia floribunda in Melanoma: Experimental and Computational Insights.

Applied biochemistry and biotechnology·2025

Related Experiment Video

Updated: Oct 26, 2025

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.2K

Caspases in the Developing Central Nervous System: Apoptosis and Beyond.

Trang Thi Minh Nguyen1, Germain Gillet1,2, Nikolay Popgeorgiev1

  • 1Centre de Recherche en Cancérologie de Lyon, U1052 INSERM, UMR CNRS 5286, Centre Léon Bérard, Université Claude Bernard Lyon 1, Lyon, France.

Frontiers in Cell and Developmental Biology
|August 2, 2021
PubMed
Summary

Caspases, key regulators of apoptosis, also play crucial roles in normal central nervous system (CNS) development. This review explores their dual functions in neural cell death and differentiation.

Keywords:
apoptosiscaspasescentral nervous systemembryonic developmentmitochondria

More Related Videos

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.5K
Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry
05:29

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry

Published on: March 24, 2023

4.9K

Related Experiment Videos

Last Updated: Oct 26, 2025

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.2K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.5K
Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry
05:29

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry

Published on: March 24, 2023

4.9K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Caspases are cysteine proteases executing programmed cell death (PCD) type I, also known as apoptosis.
  • Historically recognized for their role in eliminating cells during embryonic development, including the central nervous system (CNS).
  • Emerging evidence indicates caspases are involved in non-apoptotic neurodevelopmental processes.

Purpose of the Study:

  • To review the current understanding of both apoptotic and non-apoptotic functions of caspases in the developing CNS.
  • To explore the regulatory mechanisms governing caspase activity in neural development.
  • To emphasize the involvement of the mitochondrial pathway in caspase-mediated processes.

Main Methods:

  • Literature review synthesizing existing research on caspases in CNS development.
  • Analysis of studies investigating molecular factors regulating caspase functions.
  • Focus on the mitochondrial pathway as a key regulatory hub.

Main Results:

  • Caspases are essential for programmed cell death in the CNS.
  • Beyond cell death, caspases actively participate in axon guidance, synapse formation, and synaptic function.
  • The mitochondrial pathway is a critical regulator of caspase-mediated apoptotic and non-apoptotic roles.

Conclusions:

  • Caspases exhibit a dual role in the developing CNS, mediating both cell death and essential developmental processes.
  • Understanding caspase regulation is key to deciphering neural cell fate decisions during development.
  • The mitochondrial pathway is central to controlling these diverse caspase activities.