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Long-Term Course of Polymorphic Light Eruption: A Registry Analysis.

Alexandra Gruber-Wackernagel¹, Tanja Schug¹, Thomas Graier¹

¹Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Frontiers in Medicine

|August 2, 2021

Summary

Polymorphic light eruption (PLE) often persists for many years, but symptoms typically improve or resolve over time. A significant majority of patients continue to experience PLE even after two decades.

Keywords:

disease course persistence polymorphic light eruption predictive factors remission

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Area of Science:

Dermatology
Photodermatology

Background:

The long-term prognosis of polymorphic light eruption (PLE) is not well-established.
Understanding the disease course is crucial for patient management and counseling.

Purpose of the Study:

To investigate the long-term course and predict disease progression in patients with polymorphic light eruption (PLE).

Main Methods:

A questionnaire was mailed to 205 patients diagnosed with PLE between 1990 and 2018.
Patients reported on symptom normalization, improvement, stability, or worsening over time.
Kaplan-Meier analysis was used to estimate disease persistence.

Main Results:

Of 97 respondents, 74% still suffered from PLE after 20 years.
Symptoms resolved in 41% of females and 24% of males, with a mean resolution time of 17.4 and 11.8 years, respectively.
PLE lesion persistence longer than one week was associated with a prolonged disease course.

Conclusions:

Polymorphic light eruption (PLE) typically follows a chronic course lasting many years.
While symptoms often improve or resolve, a substantial proportion of patients experience persistent disease.
Further research is needed to understand the mechanisms underlying symptom improvement in PLE.