Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone Mineral Density Loss in Relapsing-remitting Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Matched Case-control Study.

International journal of preventive medicine·2026
Same author

Blood donor deferral patterns in Iran: six-year national analysis (2016-2021).

Blood transfusion = Trasfusione del sangue·2026
Same author

Mechanical and durability performance of gypseous soils stabilized with zeolite and lime.

Scientific reports·2026
Same author

Cognitive Impairment and Quality of Life in AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study in Iranian Patients.

Neurology research international·2026
Same author

A dual-drug chitosan-hyaluronic acid bandage contact lens accelerates corneal re-epithelialization in a rabbit mechanical debridement model.

Scientific reports·2026
Same author

A Functional Shape Framework for the Detection of Multiple Sclerosis Using Optical Coherence Tomography Images.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Oct 26, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.3K

Retinal OCT Texture Analysis for Differentiating Healthy Controls from Multiple Sclerosis (MS) with/without Optic

Hamidreza Dehghan Tazarjani1, Zahra Amini1, Rahele Kafieh1

  • 1Medical Image and Signal Processing Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Biomed Research International
|August 2, 2021
PubMed
Summary

Texture features from Optical Coherence Tomography (OCT) images show promise for diagnosing multiple sclerosis (MS). Combining texture analysis with retinal layer thickness improves diagnostic accuracy for MS, including cases with and without optic neuritis (ON).

More Related Videos

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.2K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.6K

Related Experiment Videos

Last Updated: Oct 26, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.3K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.2K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.6K

Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is a central and peripheral nervous system inflammatory disease.
  • Optic neuritis (ON) is a common ocular manifestation of MS.
  • Current MS diagnosis relies on MRI, but Optical Coherence Tomography (OCT) shows potential for early detection.

Purpose of the Study:

  • To introduce a novel pipeline for constructing layer-stacked (LS) images from OCT data.
  • To extract and evaluate texture features from LS images for differentiating healthy controls (HC) from MS patients (with and without ON).
  • To assess the combined diagnostic power of texture features and conventional retinal layer thickness values.

Main Methods:

  • Development of a pipeline to create LS images from OCT scans, isolating data from specific neural retinal layers.
  • Extraction of a comprehensive set of tailored texture features from LS images.
  • Comparative analysis of texture features and thickness values for classifying HC, MS (ON), and MS (None-ON) groups.

Main Results:

  • Texture features extracted from LS images demonstrate significant ability in diagnosing MS cases.
  • The combination of texture features and conventional thickness values substantially enhances discrimination between HC and MS groups (including HC vs. MS-ON and HC vs. MS-None-ON).

Conclusions:

  • Texture analysis of OCT-derived LS images offers a powerful tool for MS diagnosis.
  • Integrating texture features with thickness measurements improves diagnostic performance, aiding in the differentiation of healthy individuals from MS patients.