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Association and diagnostic value of a novel uric acid index to cardiovascular risk

Ricardo Rojas-Humpire1, Keila Jáuregui-Rodríguez1, Silvana Albornoz1

  • 1Departamento de Ciencias Básicas, Escuela de Medicina Humana, Facultad de Ciencias de La Salud, Universidad Peruana Unión, Lima, Peru.

Practical Laboratory Medicine
|August 2, 2021
PubMed

Insights

A new uric acid index (UA index) shows a significant association with cardiovascular risk (CVR) in Peruvian adults. This novel marker demonstrates good diagnostic accuracy for identifying high CVR, outperforming uric acid alone.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Cardiovascular diseases (CVD) represent a major global health burden.
  • Accurate assessment of cardiovascular risk (CVR) is crucial for prevention strategies.
  • Novel biomarkers are needed to improve CVR prediction.

Purpose of the Study:

  • To evaluate the association between a novel uric acid index (UA index) and CVR.
  • To determine the diagnostic value of the UA index in identifying high CVR.
  • To compare the UA index with traditional risk factors and uric acid alone.

Main Methods:

  • An analytical cross-sectional study was conducted in Peru.
  • The QRISK model was used to assess CVR.
  • Stepwise regression and Poisson regression models were employed to analyze the UA index and CVR association, with ROC curves for diagnostic accuracy.

Main Results:

  • The UA index showed a stronger correlation with CVR (R: 0.31) than uric acid alone (R: 0.19).
  • The UA index was an independent predictor of CVR (PRa: 1.58, CI95% 1.11-2.24).
  • Diagnostic accuracy was good in both men (AUC: 0.81) and women (AUC: 0.77).

Conclusions:

  • The UA index is a valuable tool for assessing CVR in adults.
  • It demonstrates significant independent association and good diagnostic accuracy for high CVR.
  • This marker can aid in primary healthcare for CVR assessment and monitoring treatment progress.
Abstract

Keywords:
BiomarkerCardiometabolic risk factorsCardiovascular diseasePrimary health careUric acid

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