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Sarah M Anthony¹, Laura G Wonilowicz¹, Matthew S McVeigh¹

¹Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.

|August 2, 2021

Summary

This summary is machine-generated.

Transient cyclic alkynes and allenes, once curiosities, are now key synthetic building blocks. Recent advances, including asymmetric catalysis, enable complex structures from these reactive intermediates.

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Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Arynes, strained cyclic alkynes, and strained cyclic allenes were recognized as intermediates in the mid-20th century.
Initially viewed as scientific curiosities due to their transient and reactive nature.

Purpose of the Study:

To highlight recent advancements in the synthetic utility of arynes, strained cyclic alkynes, and strained cyclic allenes.
To showcase how these reactive species are now valuable building blocks in organic synthesis.

Main Methods:

Review of recent literature focusing on the synthesis and application of strained cyclic intermediates.
Emphasis on breakthroughs in asymmetric catalysis for controlling stereochemistry.

Main Results:

Demonstration of access to significant structural and stereochemical complexity using these intermediates.
Highlighting the evolution from mere curiosities to versatile synthetic tools.

Conclusions:

Arynes, strained cyclic alkynes, and allenes are now indispensable in modern synthetic chemistry.
Asymmetric catalysis has been pivotal in unlocking the potential of these reactive species for complex molecule construction.