Related Experiment Video
Updated: Oct 26, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
Prognostic value of right ventricular echocardiographic measures in patients with heart failure with reduced ejection
Ingrid Josefine Lundorff1, Morten Sengeløv1, Sune Pedersen1,2
1Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Purpose:
Right ventricular (RV) dysfunction is associated with poor outcome in patients with heart failure. In order to better predict mortality in this patient group we wanted to compare the prognostic value of conventional and advanced RV echocardiographic measures.
Methods:
Echocardiographic examinations were retrieved from 701 patients. End point was all-cause mortality and follow-up 100%. RV parameters were measured offline in accordance with current guidelines. Speckle tracking was derived using the algorithm originally designed for the left ventricle.
Results:
During follow-up (median: 39 months) 118 patients (16.8%) died. RV global longitudinal strain (GLS) and RV free wall strain (FWS) remained associated with mortality after multivariable adjustment independent of Tricuspid annular plane systolic excursion (TAPSE) (RV GLS: HR 1.07, 95%CI 1.02-1.13, p = 0.010, per 1% decrease) (RV FWS: HR 1.05, 95%CI 1.01-1.09, p = 0.010, per 1% decrease). This seemed to be caused by significant associations in men. All RV estimates provided prognostic information incremental to established risk factors and significantly increased C-statistics.
Conclusions:
RV GLS and FWS were associated with mortality in HFrEF patients after multivariable adjustment independent of TAPSE. TAPSE, however, remained as the strongest prognosticator in women. More research is needed to identify whether speckle tracking could be superior to conventional RV measures in identifying HFrEF patients with poor outcome.
More Related Videos
10:33Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Related Concept Videos
Pathophysiology of Heart Failure
Mitral Regurgitation I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Heart Failure II: Pathophysiology
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Heart Failure IV: Classification and Diagnostic Evaluation