Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

39.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
39.8K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

171
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
171
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

327
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
327
Regulation of Metabolism01:19

Regulation of Metabolism

10.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.5K
Introduction to Metabolism01:30

Introduction to Metabolism

990
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
990

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling.

bioRxiv : the preprint server for biology·2026
Same author

Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.

Signal transduction and targeted therapy·2026
Same author

Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease.

Nature genetics·2026
Same author

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency.

bioRxiv : the preprint server for biology·2026
Same author

Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis.

Life metabolism·2026

Related Experiment Video

Updated: Oct 26, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K

Interconnections between circadian clocks and metabolism.

Dongyin Guan1,2, Mitchell A Lazar1,2,3

  • 1Institute for Diabetes, Obesity, and Metabolism.

The Journal of Clinical Investigation
|August 2, 2021
PubMed
Summary

The circadian clock, regulated by core clock genes, plays a crucial role in metabolism. Environmental disruptions to these rhythms can lead to metabolic disorders, impacting human health.

More Related Videos

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.5K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.0K

Related Experiment Videos

Last Updated: Oct 26, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.5K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.0K

Area of Science:

  • Chronobiology
  • Metabolic regulation
  • Genetics

Background:

  • Circadian rhythms are fundamental biological processes synchronized with environmental light-dark cycles.
  • The core circadian clock comprises interlocking feedback loops regulating physiological functions.
  • Emerging evidence links core circadian clock genes to specific metabolic roles.

Purpose of the Study:

  • To review the role of core circadian clock genes in metabolism.
  • To explore how environmental factors disrupt circadian rhythms and cause metabolic disorders.
  • To summarize the interplay between circadian clocks and metabolism and identify knowledge gaps.

Main Methods:

  • Review of current literature on circadian clock genes and metabolism.
  • Analysis of data from genetically modified animal models.
  • Synthesis of evidence on environmental impacts on circadian physiology.

Main Results:

  • Core circadian clock genes have distinct functions in regulating metabolism.
  • Environmental stimuli (artificial light, diet, eating/exercise timing) significantly alter circadian processes.
  • Disrupted circadian rhythms are associated with metabolic dysregulation and disease.

Conclusions:

  • The circadian clock and metabolism are reciprocally regulated.
  • Understanding these interactions is crucial for addressing metabolic disorders.
  • Further research is needed to explore therapeutic applications for human health.