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Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level
Kadriye Yakut1, Fatma Doğa Öcal1, Cem Sanhal2
1Perinatology Department Ankara, Turkish Ministry of Health Ankara City Hospital, Turkey.
Introduction:
We investigated the effect of epilepsy on cord blood oxidative stress status.
Material And Methods:
Thirty (n = 30) pregnant women with epilepsy and thirty (n = 30) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured.
Results:
Decreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P < 0.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5 miutes were lower in the epilepsy group (respectively; p = 0.012, p = 0.010). A negative correlation was found between IMA and cord pH value (r = 0.288 p = 0.034).
Conclusion:
This study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.
