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Outcome measures assisting treatment optimization in multiple sclerosis.

Gabriel Pardo1, Samantha Coates2, Darin T Okuda3

  • 1OMRF Multiple Sclerosis Center of Excellence, Oklahoma Medical Research Foundation, 820 NE 15th Street, Oklahoma City, OK, 73104, USA. gabriel-pardo@omrf.org.

Journal of Neurology
|August 2, 2021
PubMed
Summary
This summary is machine-generated.

This review explores tools for monitoring multiple sclerosis (MS) progression to optimize patient therapy. Advances in assessment, including new technologies, enhance the management of this neurological condition.

Keywords:
CognitionDexterityFunctionMonitoring modalitiesMultiple sclerosis

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Area of Science:

  • Neurology
  • Clinical Assessment
  • Disease Progression Monitoring

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease requiring continuous monitoring.
  • Assessing disease stability and progression is crucial for effective management of persons with MS (pwMS).
  • The Expanded Disability Status Scale (EDSS) has been a foundational tool since 1983.

Purpose of the Study:

  • To review instruments used for assessing disease stability or progression in pwMS.
  • To identify tools that can guide clinicians in optimizing MS therapy.
  • To explore modalities for monitoring symptoms and disease evolution in MS.

Main Methods:

  • A non-systematic review of scientific literature was conducted.
  • Exploration of various modalities for monitoring MS symptoms and disease progression.
  • Focus on instruments relevant to both MS research and clinical management.

Main Results:

  • Numerous outcome measures and tools have been developed for MS.
  • These tools assess various aspects of MS and its resulting neurological impairment.
  • The development of monitoring tools has evolved significantly since the introduction of the EDSS.

Conclusions:

  • Significant progress has been made in managing and evaluating MS progression.
  • Emerging technologies like wearable sensors offer new avenues for assessing function, dexterity, and cognition.
  • Ongoing research and technological advancements continue to improve the treatment of MS.