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Updated: Oct 26, 2025

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Decreased fasting serum glucogenic amino acids with a higher compared to normal protein diet during energy
A R Ogilvie1, M Watford1, G Wu2
1Department of Nutritional Sciences, Rutgers University and NJ-Institute of Food Health and Nutrition, New Brunswick, NJ, USA.
Abstract:
Dietary protein alters circulating amino acid (AAs) levels and higher protein intake (HP) is one means of losing weight. We examined 34 overweight and obese women (57 ± 4 years) during 6 months of energy restriction (7.3 ± 3.8% weight loss) divided into groups consuming either normal protein (NP; 18.6 energy% protein) or HP (24.3 energy% protein). There was a reduction in fasting serum glucogenic AAs (p = 0.015) that also associated with greater weight loss (p < 0.05) in the HP group, but not in the NP group. These findings have implications for nutrient prioritization during energy restriction.
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