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Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction

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3D Models for Ovarian Cancer.

Verena Kast¹, Daniela Loessner^2,3,4,5

¹Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Straβe, Dresden, Germany.

Advances in Experimental Medicine and Biology

|August 2, 2021

Summary

Developing better ovarian cancer models is crucial for improving patient survival. Advanced 3D cell culture techniques help researchers understand the tumor microenvironment and test new therapies.

Keywords:

3D cell culture Cancer-on-a-chip Hydrogels Organoids Organotypic cultures Scaffolds Spheroids Tumour microenvironment

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Published on: August 28, 2012

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Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

Area of Science:

Oncology
Biomedical Engineering
Cell Biology

Background:

Ovarian cancer survival rates have stagnated due to "one-size-fits-all" treatments and inadequate experimental models for advanced disease stages.
The tumor microenvironment significantly impacts ovarian cancer's peritoneal spread and therapeutic response.
Three-dimensional (3D) cell culture models are emerging as vital tools for studying the tumor microenvironment in cancer progression and treatment.

Purpose of the Study:

To describe the ovarian cancer tumor microenvironment.
To review advanced 3D cell culture models for ovarian cancer research.
To highlight methods mimicking the tumor microenvironment for improved therapeutic development.

Main Methods:

Review of existing literature on ovarian cancer tumor microenvironment.
Description of various 3D cell culture models: spheroids, organoids, and organotypic models.
Discussion of enabling technologies: hydrogels, scaffolds, and cancer-on-a-chip devices.

Main Results:

The tumor microenvironment plays a critical role in ovarian cancer progression and treatment resistance.
3D culture models offer a more biologically relevant platform than traditional 2D cultures.
Various innovative tools are being developed to better recapitulate the complex tumor microenvironment in vitro.

Conclusions:

Advanced 3D cell culture models are essential for overcoming limitations in current ovarian cancer research.
Mimicking the tumor microenvironment in experimental models is key to developing more effective ovarian cancer therapies.
Further development and application of these models promise to accelerate progress in ovarian cancer treatment and improve patient outcomes.