Related Experiment Videos
Protective effectiveness of an endotoxin-depleted pertussis vaccine
1Department of Bacteriology, Hospital for Sick Children, Toronto, Ontario, Canada.
Vaccine
|December 1, 1987
Abstract:
Pertussis vaccine depleted of endotoxin by the polymyxin-Sepharose affinity chromatography method was tested for toxic activity and protective effectiveness in mice. Preparations containing 1000-fold and 1 000 000-fold less endotoxin fulfilled the established experimental criteria for freedom from toxicity. A fourfold concentrate of the former demonstrated a protection rate only 10% less than that of standard, untreated pertussis vaccine.